L-PYROGLUTAMIC ACID CAS NO 149-87-1 C5H7NO3

Technical Data Sheet

                  L-Pyroglutamic acid（H-Pyr-OH）

Chemical Name: L-Pyroglutamic acid, H-Pyr-OH

Chinese Name: L-焦谷氨酸

CAS No.:98-79-3 Molecular Formula:C₅H₇NO₃ Molecular Weight :129g/mol

Structure:

Introduction:

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied Amino Acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers

Specifications:

Appearance: White crystalline powder

Specific rotation(a)D20 (C=2,H₂O) : -11.0º to –12.0º

Melting Point (ºC): 158.0ºC to 163.0 ºC

Chloride (Cl): Not more than 0.02%

Ammonium(NH4): Not more than 0.02%

Sulfate (SO4): Not more than 0.020%

Iron(Fe): Not more than 10ppm

Heavy metal(Pb): Not more than 10ppm

Arsenic(As2O3): Not more than 1ppm

Loss on drying: Not more than 0.50%

Residue on ignition: Not more than 0.2%

Assay: 98.5 to 101.0%

Applications:

l  Medical intermediates, body supplements.

It has strong moisturizing function and strong penetration in skin. As a highly nutritious and easily   absorbed additive, it can regulate the skin and act as a moisturizer.

Package:

Packing volumes: 25kg

Package: paper drums

Transportation: by sea or by air or by land

Ronas Chemical Ind.c Co., Ltd. is a chemical manufacturer and supplier in China, starting with Ammonium persulfate , Potassium Persulfate and Sodium persulfate , Ammonium Perchlorate, and Potassium Perchlorate since 1980.

Our company specializes in foreign trade procurement. We have a complete range of products, such as Ingredients For DNA Or DHA, and series of other lines, such as

,Amino Acid，Amino Acid Derivatives，Pharmaceutical Intermediates，Ingredients For DNA Or DHA, Boc Protect Amino Acids, Heterocyclic Compounds, Small Molecule Peptide, Cosmetic Ingredients, Ammonium persulfate, Amino acid Esters , Sodium persulfate, Amino AciD,

Cosmetic Peptide , Fmoc protect amino acids etc. Please feel free to contact us if you need more assistance.